The Hayne Lab

Hayne, CK^†, Butay JK, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch R, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE^†. Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex. Nat Struct Mol Biol (2023). doi: 10.1038/s41594-023-00991-z         

^†denotes co-corresponding authors.  

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Hayne CK, Lewis, TA, Stanley RE. Recent insights into the structure, function and regulation of the eukaryotic tRNA splicing endonuclease complex. WIRES RNA. 2022, e1717. doi: 10.1002/wrna.1717

Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun. 2021 Jan 27;12(1):636. doi: 10.1038/s41467-020-20608-z.

Hayne CK, Schmidt CA, Haque MI, Matera AG, Stanley RE. Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage. Nucleic Acids Res. 2020 Aug 20;48(14):7609-7622. doi: 10.1093/nar/gkaa438.

“NAR Breakthrough Article”

Hayne CK, Yumerefendi H, Cao L, Gauer JW, Lafferty MJ, Kuhlman B, Erie DA, Neher SB. We FRET so You Don’t Have To: New Models of the Lipoprotein Lipase Dimer. Biochemistry. 2018 Jan 16;57(2):241-254. doi: 10.1021/acs.biochem.7b01009. Epub 2018 Jan 5.

Hayne CK, Lafferty MJ, Eglinger BJ, Kane JP, Neher SB. Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake. Biochemistry. 2017 Jan 24;56(3):525-533. doi: 10.1021/acs.biochem.6b00945. Epub 2017 Jan 9.

Garrett CK, Broadwell LJ, Hayne CK, Neher SB. Modulation of the Activity of Mycobacterium tuberculosis LipY by Its PE Domain. PLoS One. 2015;10(8):e0135447. doi: 10.1371/journal.pone.0135447. eCollection 2015.